Tbc1d22a | TBC1 domain family, member 22a

GeneMGI:1289265Synonyms: D15Ertd781e

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating amylase level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.33x10^-12
decreased circulating fructosamine level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.16x10^-6
thrombocytopenia	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.94x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.05x10^-19
increased circulating alanine transaminase level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.95x10^-34
increased circulating creatinine level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.88x10^-5
increased circulating free fatty acids level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.54x10^-6
increased mean platelet volume	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.66x10^-6
increased red blood cell distribution width	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.08x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Tbc1d22a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.62x10^-53

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tbc1d22a.

Associated images

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Histopathology

There is no histopathology data found for Tbc1d22a.

IMPC related publications

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External links

No external links available for Tbc1d22a.

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*Tbc1d22a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tbc1d22a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tbc1d22a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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