Kcnn4 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

GeneMGI:1277957Synonyms: SK4, IKCa1, +3 more

Physiological systems

23 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hematopoietic system Craniofacial Cardiovascular system Homeostasis/metabolism Limbs/digits/tail Liver/biliary system Behavior/neurological Skeleton

9 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:25Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased red blood cell distribution width	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.11x10^-12
small seminal vesicle	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal colon morphology	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
small heart	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal digit morphology	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.69x10^-8
increased fasting circulating glucose level	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.47x10^-8
abnormal testis morphology	1 supporting dataset	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Kcnn4^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kcnn4.

Associated images

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Histopathology

There is no histopathology data found for Kcnn4.

IMPC related publications

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External links

No external links available for Kcnn4.

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*Kcnn4^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse
*Kcnn4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Kcnn4^{tm245315(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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