Gfi1b | growth factor independent 1B

GeneMGI:1276578Synonyms: Gfi-1B

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Hematopoietic system Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased total body fat amount	2 supporting datasets	Gfi1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.79x10^-6
decreased neutrophil cell number	2 supporting datasets	Gfi1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.65x10^-10
increased circulating bilirubin level	1 supporting dataset	Gfi1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.06x10^-5
increased circulating serum albumin level	1 supporting dataset	Gfi1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.7x10^-5
increased lymphocyte cell number	1 supporting dataset	Gfi1b^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.34x10^-7
prenatal lethality	1 supporting dataset	Gfi1b^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Gfi1b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gfi1b.

Associated images

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Histopathology

There is no histopathology data found for Gfi1b.

IMPC related publications

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External links

No external links available for Gfi1b.

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*Gfi1b^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Gfi1b^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Gfi1b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Gfi1b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gfi1b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Gfi1b^{tm26477(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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