Zfp106 | zinc finger protein 106
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Growth/size/body region Behavior/neurological
16 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating calcium level | 1 supporting dataset | Zfp106tm1a(KOMP)Wtsi | heterozygote | Early adult | 3.98x10-8 | ||
| increased thermal nociceptive threshold | 1 supporting dataset | Zfp106tm1a(KOMP)Wtsi | homozygote | Early adult | 4.44x10-16 | ||
| abnormal posture | 1 supporting dataset | Zfp106tm1a(KOMP)Wtsi | homozygote | Early adult | 6.85x10-12 | ||
| decreased body weight | 2 supporting datasets | Zfp106tm1a(KOMP)Wtsi | homozygote | Early adult | 1.76x10-9 | ||
| abnormal gait | 1 supporting dataset | Zfp106tm1a(KOMP)Wtsi | homozygote | Early adult | 1.06x10-7 | ||
| abnormal external female genitalia morphology | 1 supporting dataset | Zfp106tm1a(KOMP)Wtsi | homozygote | Early adult | 6.52x10-6 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Zfp106 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Zfp106.
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| Zfp106tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Zfp106tm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Zfp106tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |