Usp12 | ubiquitin specific peptidase 12

GeneMGI:1270128Synonyms: Ubh1

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Renal/urinary system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased circulating amylase level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.12x10^-6
oligodactyly	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	7.47x10^-8
increased IgM level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.36x10^-6
abnormal urination	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.7x10^-5
decreased T cell number	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.43x10^-5
decreased mean corpuscular volume	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.28x10^-5
increased IgG3 level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.85x10^-7
increased circulating cholesterol level	1 supporting dataset	Usp12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.25x10^-5
decreased lean body mass	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	2.18x10^-5
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.75x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Usp12.

Associated images

Loading...

Histopathology

There is no histopathology data found for Usp12.

IMPC related publications

Loading...

External links

No external links available for Usp12.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Usp12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Usp12^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Usp12^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

My Genes