Usp12 | ubiquitin specific peptidase 12

GeneMGI:1270128Synonyms: Ubh1

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Renal/urinary system

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased circulating amylase level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.12x10^-6
oligodactyly	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	7.47x10^-8
increased IgM level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.36x10^-6
abnormal urination	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	7.7x10^-5
decreased T cell number	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.43x10^-5
decreased mean corpuscular volume	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.28x10^-5
increased IgG3 level	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.85x10^-7
increased circulating cholesterol level	1 supporting dataset	Usp12^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.25x10^-5
decreased lean body mass	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	heterozygote	Early adult	2.18x10^-5
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Usp12^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.75x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Usp12.

Associated images

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Histopathology

There is no histopathology data found for Usp12.

IMPC related publications

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External links

No external links available for Usp12.

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*Usp12^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Usp12^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Usp12^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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