Pibf1 | progesterone immunomodulatory binding factor 1

GeneMGI:1261910Synonyms: 4933439E17Rik, 1700017E21Rik, +3 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Nervous system Behavior/neurological Cardiovascular system Mortality/aging

12 No significant impact

5 Not tested

Gene metrics:12Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
21Embryo tissues

Phenotypes

abnormal embryo turning1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal neural tube closure1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
abnormal heart morphology1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
increased heart weight1 supporting datasetPibf1tm1.1(KOMP)VlcgheterozygoteEarly adult1.96x10-6 
embryonic lethality prior to tooth bud stage1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
abnormal embryo size1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
increased circulating bilirubin level1 supporting datasetPibf1tm1.1(KOMP)VlcgheterozygoteEarly adult4.4x10-5 
preweaning lethality, complete penetrance1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal neural tube morphology1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
embryonic growth retardation1 supporting datasetPibf1tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pibf1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Pibf1tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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