Dnmt3a | DNA methyltransferase 3A

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Nervous system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

6Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



convulsive seizures	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.49x10^-12
increased grip strength	2 supporting datasets	Dnmt3a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.83x10^-12
increased total body fat amount	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.31x10^-5
decreased exploration in new environment	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.92x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.53x10^-6
decreased circulating glucose level	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.22x10^-5
abnormal embryo size	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
decreased circulating cholesterol level	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.1x10^-5
abnormal bone structure	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.83x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Dnmt3a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnmt3a.

Associated images

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Histopathology

There is no histopathology data found for Dnmt3a.

IMPC related publications

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External links

No external links available for Dnmt3a.

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*Dnmt3a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dnmt3a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dnmt3a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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