Tcf7l2 | transcription factor 7 like 2, T cell specific, HMG box

GeneMGI:1202879Synonyms: mTcf-4E, TCF4E, +4 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Adipose tissue Growth/size/body region Hematopoietic system Skeleton Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased lean body mass	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.22x10^-5
increased bone mineral content	2 supporting datasets	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.5x10^-5
decreased total body fat amount	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.62x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.58x10^-7
increased mean platelet volume	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.66x10^-6
increased bone mineral density	1 supporting dataset	Tcf7l2^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.61x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tcf7l2.

Associated images

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Histopathology

There is no histopathology data found for Tcf7l2.

IMPC related publications

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External links

No external links available for Tcf7l2.

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*Tcf7l2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tcf7l2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Tcf7l2^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tcf7l2^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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