Tcf7l1 | transcription factor 7 like 1 (T cell specific, HMG box)
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Craniofacial
12 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased leukocyte cell number | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.66x10-5 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.38x10-11 | ||
| abnormal cornea morphology | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.02x10-5 | ||
| abnormal vibrissa morphology | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.73x10-5 | ||
| cornea opacity | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.15x10-5 | ||
| abnormal snout morphology | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.38x10-5 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Tcf7l1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.3x10-5 |
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External links
No external links available for Tcf7l1.
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| Tcf7l1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tcf7l1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |