Ddb1 | damage specific DNA binding protein 1

GeneMGI:1202384Synonyms: DNA repair protein, p127-Ddb1, +1 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Integument Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	2 supporting datasets	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	3.05x10^-5
enlarged thymus	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal auditory brainstem response	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.6x10^-5
abnormal urinary bladder morphology	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	homozygote	E9.5	N/A ^*
enlarged urinary bladder	1 supporting dataset	Ddb1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ddb1.

Associated images

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Histopathology

There is no histopathology data found for Ddb1.

IMPC related publications

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External links

No external links available for Ddb1.

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*Ddb1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Ddb1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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