Hcrt | hypocretin

GeneMGI:1202306Synonyms: orexin B, orexin A

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Immune system Hematopoietic system Behavior/neurological Cardiovascular system

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

3Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	1 supporting dataset	Hcrt^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.11x10^-5
prolonged RR interval	1 supporting dataset	Hcrt^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.76x10^-7
decreased heart rate	1 supporting dataset	Hcrt^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4x10^-5
increased lymphocyte cell number	1 supporting dataset	Hcrt^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.68x10^-5
decreased locomotor activity	4 supporting datasets	Hcrt^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.53x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hcrt.

Associated images

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Histopathology

There is no histopathology data found for Hcrt.

IMPC related publications

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External links

No external links available for Hcrt.

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*Hcrt^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Hcrt^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

My Genes