Atp6v0d1 | ATPase, H+ transporting, lysosomal V0 subunit D1

GeneMGI:1201778Synonyms: Vma6, lysosomal 38kDa, +3 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	2 supporting datasets	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased neutrophil cell number	2 supporting datasets	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.46x10^-9
short tibia	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.68x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.66x10^-5
decreased lymphocyte cell number	1 supporting dataset	Atp6v0d1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.51x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp6v0d1.

Associated images

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Histopathology

There is no histopathology data found for Atp6v0d1.

IMPC related publications

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External links

No external links available for Atp6v0d1.

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*Atp6v0d1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Atp6v0d1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Atp6v0d1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atp6v0d1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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