Rnf4 | ring finger protein 4

GeneMGI:1201691Synonyms: Gtrgeo8

Physiological systems

23 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Embryo Growth/size/body region Behavior/neurological Mortality/aging

16 No significant impact

1 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal testis morphology1 supporting datasetRnf4em1(IMPC)CcpczheterozygoteEarly adultN/A * 
preweaning lethality, complete penetrance1 supporting datasetRnf4em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased circulating total protein level1 supporting datasetRnf4em1(IMPC)CcpczheterozygoteEarly adult2.67x10-7 
small testis1 supporting datasetRnf4em1(IMPC)CcpczheterozygoteEarly adultN/A * 
abnormal embryo size1 supporting datasetRnf4em1(IMPC)CcpczhomozygoteE18.5N/A * 
no spontaneous movement1 supporting datasetRnf4em1(IMPC)CcpczhomozygoteE18.5N/A * 
increased circulating triglyceride level1 supporting datasetRnf4em1(IMPC)CcpczheterozygoteEarly adult3.8x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rnf4em1(IMPC)CcpczExon Deletionmouse

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