Eomes | eomesodermin

GeneMGI:1201683Synonyms: Tbr2

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased bone mineral content	1 supporting dataset	Eomes^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.27x10^-5
increased total body fat amount	2 supporting datasets	Eomes^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.51x10^-7
decreased circulating creatinine level	1 supporting dataset	Eomes^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.3x10^-5
decreased lean body mass	2 supporting datasets	Eomes^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Eomes^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Eomes^{tm1b(EUCOMM)Wtsi}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Eomes^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Eomes.

Associated images

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Histopathology

There is no histopathology data found for Eomes.

IMPC related publications

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External links

No external links available for Eomes.

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*Eomes^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Eomes^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Eomes^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Eomes^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Eomes^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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