Nlk | nemo like kinase

GeneMGI:1201387

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased startle reflex	1 supporting dataset	Nlk^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	2.53x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Nlk^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	4.88x10^-5
abnormal auditory brainstem response	1 supporting dataset	Nlk^{tm2b(KOMP)Wtsi}	heterozygote	Early adult	6.09x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Nlk^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nlk.

Associated images

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Histopathology

There is no histopathology data found for Nlk.

IMPC related publications

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External links

No external links available for Nlk.

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*Nlk^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Nlk^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nlk^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nlk^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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