Dsg2 | desmoglein 2
Physiological systems
16 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Muscle Mortality/aging Cardiovascular system
12 No significant impact
8 Not tested
Data collections
Gene metrics:4Significant phenotypes
6Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
| dilated heart left ventricle | 2 supporting datasets | Dsg2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.84x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dsg2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased cardiac muscle contractility | 2 supporting datasets | Dsg2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.33x10-6 | ||
| abnormal coat appearance | 1 supporting dataset | Dsg2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.34x10-9 |
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External links
No external links available for Dsg2.
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| Dsg2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dsg2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dsg2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dsg2tm48337(pL1L2_GT0_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |