Fndc3a | fibronectin type III domain containing 3A

GeneMGI:1196463Synonyms: Fndc3, F730017H24Rik, +3 more

Physiological systems

17 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

6 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased lean body mass	2 supporting datasets	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	6.73x10^-18
abnormal retina vasculature morphology	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	5.69x10^-7
decreased locomotor activity	2 supporting datasets	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	3.99x10^-6
decreased heart weight	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	3.38x10^-6
abnormal retina blood vessel morphology	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	6.33x10^-7
decreased body length	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	3.99x10^-5
increased total body fat amount	2 supporting datasets	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	2.74x10^-17
decreased circulating serum albumin level	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	8.47x10^-5
decreased exploration in new environment	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	6.51x10^-5
increased lymphocyte cell number	1 supporting dataset	Fndc3a^em1(IMPC)Tcp	homozygote	Early adult	4.21x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fndc3a.

Associated images

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Histopathology

There is no histopathology data found for Fndc3a.

IMPC related publications

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External links

No external links available for Fndc3a.

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*Fndc3a^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Fndc3a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Fndc3a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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