Scarb2 | scavenger receptor class B, member 2

GeneMGI:1196458Synonyms: LIMP II, LIMP-2, +3 more

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Skeleton Cardiovascular system Mortality/aging Renal/urinary system

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased lymphocyte cell number	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	1.34x10^-6
decreased mean corpuscular volume	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	4.2x10^-5
increased leukocyte cell number	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	5.31x10^-9
increased heart rate variability	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	1.78x10^-7
thrombocytosis	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	3.24x10^-7
abnormal QT variability	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	8.13x10^-5
prolonged RR interval	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	2.11x10^-5
enlarged lymph nodes	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased total body fat amount	2 supporting datasets	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	2.19x10^-16
increased blood urea nitrogen level	1 supporting dataset	Scarb2^em2(IMPC)Tcp	homozygote	Early adult	6.43x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Scarb2.

Associated images

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Histopathology

There is no histopathology data found for Scarb2.

IMPC related publications

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External links

No external links available for Scarb2.

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*Scarb2^em2(IMPC)Tcp*	Indel	‌	mouse
*Scarb2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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