Pja1 | praja ring finger ubiquitin ligase 1

GeneMGI:1101765Synonyms: Praja-1

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased B cell number	1 supporting dataset	Pja1^PJA1	hemizygote	Early adult	1.8x10^-5
microphthalmia	1 supporting dataset	Pja1^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Pja1^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
cataract	1 supporting dataset	Pja1^em1(IMPC)Mbp	homozygote	Early adult	7.32x10^-5
microphthalmia	1 supporting dataset	Pja1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Pja1^em1(IMPC)Mbp	hemizygote	Early adult	N/A ^*
decreased locomotor activity	2 supporting datasets	Pja1^em1(IMPC)Mbp	homozygote	Early adult	1.46x10^-6
enlarged ovary	1 supporting dataset	Pja1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Pja1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Pja1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pja1.

Associated images

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Histopathology

There is no histopathology data found for Pja1.

IMPC related publications

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External links

No external links available for Pja1.

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*Pja1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Pja1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Pja1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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