Elavl1 | ELAV like RNA binding protein 1

GeneMGI:1100851Synonyms: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R), Hua, +3 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating alanine transaminase level	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.27x10^-6
abnormal embryo size	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
impaired pupillary reflex	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.48x10^-11
embryonic growth retardation	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
decreased mean corpuscular hemoglobin	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.39x10^-6
anophthalmia	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
abnormal limb morphology	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Elavl1^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Elavl1.

Associated images

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Histopathology

There is no histopathology data found for Elavl1.

IMPC related publications

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External links

No external links available for Elavl1.

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*Elavl1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Elavl1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Elavl1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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