Dhx15 | DEAH-box helicase 15

GeneMGI:1099786Synonyms: Ddx15, mDEAH9, +3 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Nervous system Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased hematocrit	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	6.19x10^-5
preweaning lethality, complete penetrance	2 supporting datasets	Dhx15^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Dhx15^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	9.8x10^-9
cataract	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	9.13x10^-8
shortened QT interval	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	2.83x10^-5
abnormal lens morphology	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	2.81x10^-7
decreased prepulse inhibition	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	8.08x10^-8
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	8.85x10^-5
increased erythrocyte cell number	1 supporting dataset	Dhx15^em1(IMPC)Tcp	heterozygote	Early adult	5.6x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dhx15.

Associated images

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Histopathology

There is no histopathology data found for Dhx15.

IMPC related publications

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External links

No external links available for Dhx15.

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*Dhx15^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Dhx15^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dhx15^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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