Tmc6 | transmembrane channel-like gene family 6

GeneMGI:1098686Synonyms: EVER1, D11Ertd204e

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Skeleton Cardiovascular system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



vertebral fusion	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.02x10^-5
decreased circulating cholesterol level	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.8x10^-5
decreased circulating serum albumin level	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.81x10^-5
increased lean body mass	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.97x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.72x10^-6
increased heart weight	1 supporting dataset	Tmc6^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmc6.

Associated images

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Histopathology

There is no histopathology data found for Tmc6.

IMPC related publications

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External links

No external links available for Tmc6.

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*Tmc6^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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