Stag1 | STAG1 cohesin complex component

GeneMGI:1098658Synonyms: Scc3, SA-1

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Stag1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal urinary bladder morphology	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Stag1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta vasculature	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Stag1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal placenta morphology	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
small kidney	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	Late adult	N/A ^*
enlarged seminal vesicle	1 supporting dataset	Stag1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Stag1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Stag1.

Associated images

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Histopathology

There is no histopathology data found for Stag1.

IMPC related publications

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External links

No external links available for Stag1.

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*Stag1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Stag1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Stag1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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