Cast | calpastatin

GeneMGI:1098236

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Growth/size/body region Limbs/digits/tail Behavior/neurological Cardiovascular system

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:49Adult tissues

46Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.14x10^-7
decreased fasting circulating glucose level	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.43x10^-5
decreased startle reflex	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.03x10^-6
abnormal digit morphology	2 supporting datasets	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.18x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.05x10^-8
abnormal nail morphology	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.18x10^-5
abnormal gait	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.11x10^-8
increased circulating sodium level	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.54x10^-5
increased circulating phosphate level	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.19x10^-6
abnormal limb position	1 supporting dataset	Cast^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.4x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cast.

Associated images

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Histopathology

There is no histopathology data found for Cast.

IMPC related publications

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External links

No external links available for Cast.

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*Cast^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Cast^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Cast^{tm452444(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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