Cenpe | centromere protein E

GeneMGI:1098230Synonyms: 312kDa, CENP-E, +2 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

3Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal lens morphology	1 supporting dataset	Cenpe^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.21x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Cenpe^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating lipase level	1 supporting dataset	Cenpe^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.62x10^-8
cataract	1 supporting dataset	Cenpe^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.06x10^-5
increased fasting circulating glucose level	1 supporting dataset	Cenpe^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.38x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cenpe.

Associated images

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Histopathology

There is no histopathology data found for Cenpe.

IMPC related publications

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External links

No external links available for Cenpe.

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*Cenpe^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cenpe^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cenpe^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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