Bhlhe40 | basic helix-loop-helix family, member e40

GeneMGI:1097714Synonyms: Bhlhb2, CR8, +8 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.31x10^-6
decreased circulating glycerol level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.01x10^-5
increased circulating chloride level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.81x10^-7
decreased fasting circulating glucose level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.51x10^-6
decreased circulating cholesterol level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.89x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.18x10^-7
increased heart weight	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.16x10^-6
increased circulating fructosamine level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.23x10^-10
decreased circulating calcium level	1 supporting dataset	Bhlhe40^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.41x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bhlhe40.

Associated images

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Histopathology

There is no histopathology data found for Bhlhe40.

IMPC related publications

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External links

No external links available for Bhlhe40.

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*Bhlhe40^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Bhlhe40^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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