Npc1 | NPC intracellular cholesterol transporter 1
Physiological systems
22 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Hematopoietic system Behavior/neurological Mortality/aging
18 No significant impact
2 Not tested
Gene metrics:4Significant phenotypes
6Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| increased monocyte cell number | 1 supporting dataset | Npc1tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 1.5x10-5 | ||
| increased startle reflex | 1 supporting dataset | Npc1tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 4.52x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Npc1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.6x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Npc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
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External links
No external links available for Npc1.
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| Npc1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Npc1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Npc1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | es cell |
| Npc1tm83360(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |