Hcn1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1

GeneMGI:1096392Synonyms: Bcng1, C630013B14Rik, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Hearing/vestibular/ear Behavior/neurological Cardiovascular system

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



prolonged RR interval	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	1.13x10^-11
abnormal gait	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	5.71x10^-18
decreased locomotor activity	3 supporting datasets	Hcn1^em1(IMPC)H	homozygote	Early adult	1.38x10^-5
decreased heart rate	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	7.04x10^-7
decreased exploration in new environment	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	4.06x10^-8
abnormal locomotor behavior	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	1.05x10^-5
abnormal auditory brainstem response	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	6.2x10^-5
tremors	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	8.63x10^-7
increased heart weight	1 supporting dataset	Hcn1^em1(IMPC)H	homozygote	Early adult	1.73x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hcn1.

Associated images

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Histopathology

There is no histopathology data found for Hcn1.

IMPC related publications

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External links

No external links available for Hcn1.

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*Hcn1^em1(IMPC)H*	Exon Deletion	‌	mouse
*Hcn1^em2(IMPC)H*	Exon Deletion	‌	mouse
*Hcn1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Hcn1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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