Sema3f | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

GeneMGI:1096347Synonyms: Sema IV, Semak

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Vision/eye Behavior/neurological Mortality/aging

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



decreased circulating total protein level	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.01x10^-5
decreased exploration in new environment	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.16x10^-5
limb grasping	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.86x10^-10
decreased circulating serum albumin level	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.77x10^-5
abnormal nail morphology	2 supporting datasets	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.13x10^-5
tremors	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.46x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating iron level	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.51x10^-7
iris synechia	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.58x10^-5
increased startle reflex	1 supporting dataset	Sema3f^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.02x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sema3f.

Associated images

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Histopathology

There is no histopathology data found for Sema3f.

IMPC related publications

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External links

No external links available for Sema3f.

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*Sema3f^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sema3f^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sema3f^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Sema3f^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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