E2f3 | E2F transcription factor 3

GeneMGI:1096340Synonyms: E2f3a, E2F3b

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Embryo Growth/size/body region Digestive/alimentary Behavior/neurological Craniofacial Mortality/aging

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

64Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



no spontaneous movement	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	E18.5	N/A ^*
increased startle reflex	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	2.59x10^-6
abnormal snout morphology	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	2.84x10^-5
no spontaneous movement	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
impaired glucose tolerance	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.5x10^-5
increased total body fat amount	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	1.65x10^-5
abnormal jejunum morphology	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Late adult	N/A ^*
abnormal snout morphology	1 supporting dataset	E2f3^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for E2f3.

Associated images

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Histopathology

There is no histopathology data found for E2f3.

IMPC related publications

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External links

No external links available for E2f3.

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*E2f3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*E2f3^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*E2f3^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*E2f3^{tm358025(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*E2f3^{tm38909(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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