Arvcf | armadillo repeat gene deleted in velocardiofacial syndrome

GeneMGI:109620

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Vision/eye Hematopoietic system Behavior/neurological Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased startle reflex	5 supporting datasets	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	6.46x10^-8
cataract	2 supporting datasets	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	1.23x10^-9
abnormal gait	2 supporting datasets	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	7.36x10^-15
abnormal lens morphology	1 supporting dataset	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	8.02x10^-6
abnormal behavior	5 supporting datasets	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	1.68x10^-7
abnormal urination	1 supporting dataset	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	6.16x10^-5
hyperactivity	1 supporting dataset	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	4.27x10^-5
increased monocyte cell number	1 supporting dataset	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	6.3x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Arvcf^{tm1e(EUCOMM)Wtsi}	homozygote	Early adult	8.78x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arvcf.

Associated images

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Histopathology

There is no histopathology data found for Arvcf.

IMPC related publications

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External links

No external links available for Arvcf.

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*Arvcf^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Arvcf^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Arvcf^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Arvcf^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell mouse
*Arvcf^{tm1e.1(EUCOMM)Wtsi}*	Promoter excision from Targeted, non-conditional allele	‌	mouse

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