Atp6v1b2 | ATPase, H+ transporting, lysosomal V1 subunit B2

GeneMGI:109618Synonyms: Atp6b2, HO57

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Hematopoietic system Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.39x10^-7
small adrenal glands	2 supporting datasets	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
decreased mean corpuscular hemoglobin	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.9x10^-15
preweaning lethality, complete penetrance	3 supporting datasets	Atp6v1b2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.31x10^-5
embryonic lethality prior to tooth bud stage	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
decreased hemoglobin content	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.38x10^-10
embryonic lethality prior to organogenesis	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
small lymph nodes	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Atp6v1b2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.8x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp6v1b2.

Associated images

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Histopathology

There is no histopathology data found for Atp6v1b2.

IMPC related publications

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External links

No external links available for Atp6v1b2.

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*Atp6v1b2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Atp6v1b2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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