Barx2 | BarH-like homeobox 2

GeneMGI:109617Synonyms: Barx2b, 2310006E12Rik

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



eyelids fail to open	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.84x10^-8
increased circulating creatine kinase level	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.99x10^-33
narrow eye opening	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.01x10^-19
increased circulating aspartate transaminase level	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.5x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal eyelid morphology	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.78x10^-21
cornea opacity	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.86x10^-14
abnormal coat/hair pigmentation	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.13x10^-12
increased circulating bilirubin level	1 supporting dataset	Barx2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.95x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Barx2.

Associated images

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Histopathology

There is no histopathology data found for Barx2.

IMPC related publications

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External links

No external links available for Barx2.

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*Barx2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Barx2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Barx2^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Barx2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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