Dnm2 | dynamin 2

GeneMGI:109547Synonyms: Dyn2, b2b2159Clo

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Nervous system Hematopoietic system Mortality/aging

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

7Associated diseases

Expression examined in:42Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	3 supporting datasets	Dnm2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.02x10^-5
hydrometra	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Dnm2^Dnm2	heterozygote	Early adult	5.15x10^-5
enlarged uterus	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
decreased mean corpuscular hemoglobin	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.71x10^-6
embryonic lethality prior to tooth bud stage	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
small superior vagus ganglion	1 supporting dataset	Dnm2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnm2.

Associated images

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Histopathology

There is no histopathology data found for Dnm2.

IMPC related publications

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External links

No external links available for Dnm2.

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*Dnm2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Dnm2^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dnm2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dnm2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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