Ptch2 | patched 2

GeneMGI:1095405Synonyms: ptc2

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Renal/urinary system

15 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
4Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

enlarged urinary bladder1 supporting datasetPtch2tm3b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased neutrophil cell number2 supporting datasetsPtch2tm3b(EUCOMM)HmguhomozygoteEarly adult2.72x10-7 
decreased lymphocyte cell number1 supporting datasetPtch2tm3b(EUCOMM)HmguhomozygoteEarly adult8.57x10-5 
increased fasting circulating glucose level1 supporting datasetPtch2tm3b(EUCOMM)HmguhomozygoteEarly adult4.15x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ptch2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Ptch2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ptch2tm3a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ptch2tm3b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Ptch2tm3e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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