Nfil3 | nuclear factor, interleukin 3, regulated

GeneMGI:109495Synonyms: E4BP4

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Vision/eye Hematopoietic system Skeleton Cardiovascular system Mortality/aging

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal cornea morphology	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.65x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased spleen weight	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.44x10^-5
abnormal cecum morphology	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small thymus	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased bone mineral content	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.29x10^-5
abnormal thymus morphology	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal pancreas morphology	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
cornea vascularization	1 supporting dataset	Nfil3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.08x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nfil3.

Associated images

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Histopathology

There is no histopathology data found for Nfil3.

IMPC related publications

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External links

No external links available for Nfil3.

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*Nfil3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Nfil3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Nfil3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Nfil3^{tm231068(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Nfil3^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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