Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

GeneMGI:109484Synonyms: 14-3-3 zeta, 1110013I11Rik

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Cardiovascular system Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

51Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



short tibia	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.13x10^-5
edema	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Ywhaz^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased lymphocyte cell number	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.91x10^-7
abnormal skin morphology	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased leukocyte cell number	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.01x10^-7
enlarged lymph nodes	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.53x10^-9
abnormal sinus arrhythmia	1 supporting dataset	Ywhaz^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.58x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ywhaz.

Associated images

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Histopathology

There is no histopathology data found for Ywhaz.

IMPC related publications

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External links

No external links available for Ywhaz.

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*Ywhaz^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ywhaz^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ywhaz^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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