Atf2 | activating transcription factor 2

GeneMGI:109349Synonyms: ATF-2, Creb2, +3 more

Physiological systems

23 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Respiratory system Hematopoietic system Cardiovascular system Renal/urinary system

13 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Phy. System:



enlarged heart	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal urinary bladder morphology	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.04x10^-5
decreased circulating chloride level	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.8x10^-6
abnormal skin morphology	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased lung elastance	2 supporting datasets	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.42x10^-5
decreased mean platelet volume	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.39x10^-8
abnormal spleen morphology	2 supporting datasets	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Atf2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atf2.

Associated images

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Histopathology

There is no histopathology data found for Atf2.

IMPC related publications

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External links

No external links available for Atf2.

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*Atf2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Atf2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Atf2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atf2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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