Pitx2 | paired-like homeodomain transcription factor 2

GeneMGI:109340Synonyms: Brx1b, Ptx2, +9 more

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Growth/size/body region Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Cardiovascular system Craniofacial

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

9Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal optic disk morphology	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.14x10^-17
enlarged heart	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
prenatal lethality	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
increased grip strength	2 supporting datasets	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.35x10^-9
abnormal tooth morphology	2 supporting datasets	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.77x10^-9
cornea opacity	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.13x10^-13
small testis	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	N/A ^*
irregularly shaped pupil	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.06x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Pitx2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pitx2.

Associated images

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Histopathology

There is no histopathology data found for Pitx2.

IMPC related publications

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External links

No external links available for Pitx2.

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*Pitx2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pitx2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pitx2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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