Bnip2 | BCL2/adenovirus E1B interacting protein 2

GeneMGI:109327Synonyms: 5730523P12Rik

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Craniofacial

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal incisor color	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.23x10^-17
abnormal femur morphology	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.28x10^-6
increased mean corpuscular hemoglobin	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.49x10^-9
increased grip strength	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.79x10^-5
abnormal cranium morphology	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.4x10^-5
increased lean body mass	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.44x10^-5
abnormal tibia morphology	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.26x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.66x10^-7
decreased erythrocyte cell number	1 supporting dataset	Bnip2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.61x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bnip2.

Associated images

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Histopathology

There is no histopathology data found for Bnip2.

IMPC related publications

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External links

No external links available for Bnip2.

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*Bnip2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Bnip2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Bnip2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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