Mmp15 | matrix metallopeptidase 15

GeneMGI:109320Synonyms: Membrane type 2-MMP, MT2-MMP

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Vision/eye Respiratory system Hematopoietic system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal skin coloration	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.97x10^-7
anophthalmia	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
absent lymph nodes	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating calcium level	1 supporting dataset	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.07x10^-5
abnormal trachea morphology	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal esophagus morphology	1 supporting dataset	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
athymia	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal pancreas morphology	2 supporting datasets	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal thyroid gland morphology	1 supporting dataset	Mmp15^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mmp15.

Associated images

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Histopathology

There is no histopathology data found for Mmp15.

IMPC related publications

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External links

No external links available for Mmp15.

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*Mmp15^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mmp15^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mmp15^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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