Papola | poly (A) polymerase alpha

GeneMGI:109301Synonyms: PapIII, Plap

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo size	1 supporting dataset	Papola^em1(IMPC)J	homozygote	E18.5	N/A ^*
decreased circulating calcium level	1 supporting dataset	Papola^em1(IMPC)J	heterozygote	Early adult	6.68x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Papola^em1(IMPC)J	heterozygote	Early adult	8.55x10^-8
decreased lean body mass	1 supporting dataset	Papola^em1(IMPC)J	heterozygote	Early adult	1.02x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Papola^em1(IMPC)J	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Papola.

Associated images

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Histopathology

There is no histopathology data found for Papola.

IMPC related publications

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External links

No external links available for Papola.

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*Papola^em1(IMPC)J*	Exon Deletion	‌	mouse
*Papola^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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