Pkp4 | plakophilin 4

GeneMGI:109281Synonyms: Armrp, p0071, +2 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Skeleton

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

50Embryo tissues

Phenotypes

Phy. System:



decreased circulating iron level	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.01x10^-6
impaired righting response	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.87x10^-8
abnormal sleep behavior	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.41x10^-5
decreased bone mineral content	2 supporting datasets	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.53x10^-8
decreased circulating calcium level	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.79x10^-5
abnormal bone structure	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.79x10^-5
decreased bone mineral density	1 supporting dataset	Pkp4^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.43x10^-11

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pkp4.

Associated images

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Histopathology

There is no histopathology data found for Pkp4.

IMPC related publications

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External links

No external links available for Pkp4.

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*Pkp4^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pkp4^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes