Kcnab2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2

GeneMGI:109239Synonyms: I2rf5, F5, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Adipose tissue Growth/size/body region Vision/eye Behavior/neurological

12 No significant impact

7 Not tested

Gene metrics:7Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged lymph nodes1 supporting datasetKcnab2em1(IMPC)MbphomozygoteEarly adultN/A * 
hyperactivity3 supporting datasetsKcnab2em1(IMPC)MbphomozygoteEarly adult7.35x10-6 
decreased lean body mass2 supporting datasetsKcnab2em1(IMPC)MbphomozygoteEarly adult4.22x10-15 
abnormal eye morphology1 supporting datasetKcnab2em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal lymph node morphology1 supporting datasetKcnab2em1(IMPC)MbphomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetKcnab2em1(IMPC)MbphomozygoteEarly adult5.66x10-6 
increased grip strength1 supporting datasetKcnab2em1(IMPC)MbphomozygoteEarly adult9.98x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Kcnab2em1(IMPC)MbpExon Deletionmouse
Kcnab2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Kcnab2tm1e(KOMP)WtsiTargeted, non-conditional allelees cell
Kcnab2tm2e(KOMP)WtsiTargeted, non-conditional allelees cell

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