Fgf14 | fibroblast growth factor 14

GeneMGI:109189Synonyms: Fhf4

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased body weight	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.54x10^-8
decreased grip strength	3 supporting datasets	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.43x10^-10
abnormal skin morphology	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thyroid gland	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.75x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spine curvature	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.67x10^-5
abnormal kidney morphology	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thyroid gland morphology	1 supporting dataset	Fgf14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fgf14.

Associated images

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Histopathology

There is no histopathology data found for Fgf14.

IMPC related publications

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External links

No external links available for Fgf14.

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*Fgf14^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Fgf14^{tm40450(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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