Epas1 | endothelial PAS domain protein 1

GeneMGI:109169Synonyms: HLF, hypoxia inducible transcription factor 2alpha, +6 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Adipose tissue Hematopoietic system Cardiovascular system Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased hemoglobin content	1 supporting dataset	Epas1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.31x10^-9
preweaning lethality, complete penetrance	1 supporting dataset	Epas1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased total body fat amount	1 supporting dataset	Epas1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.92x10^-5
abnormal heart morphology	1 supporting dataset	Epas1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Epas1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Epas1.

IMPC related publications

Loading...

External links

No external links available for Epas1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Epas1^{em1(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Epas1^{em2(IMPC)Wtsi}*	Point Mutation	‌	mouse
*Epas1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Epas1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Epas1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes