Sirpa | signal-regulatory protein alpha
Physiological systems
18 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system
12 No significant impact
6 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
0Embryo tissues
| increased spleen weight | 1 supporting dataset | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.29x10-20 | ||
| decreased prepulse inhibition | 1 supporting dataset | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.94x10-5 | ||
| enlarged spleen | 2 supporting datasets | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.29x10-5 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.25x10-5 | ||
| impaired glucose tolerance | 1 supporting dataset | Sirpatm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.05x10-7 |
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External links
No external links available for Sirpa.
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| Sirpatm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Sirpatm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |