Kif1b | kinesin family member 1B

GeneMGI:108426Synonyms: D4Mil1e, Kif1b alpha, +5 more

Physiological systems

19 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Craniofacial Mortality/aging Cardiovascular system

9 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

4Associated diseases

Expression examined in:48Adult tissues

53Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal facial morphology	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
hyperactivity	7 supporting datasets	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.29x10^-10
decreased thigmotaxis	2 supporting datasets	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.23x10^-5
increased startle reflex	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.79x10^-5
abnormal outer ear morphology	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
increased circulating sodium level	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.23x10^-9
unresponsive to tactile stimuli	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	homozygote	E18.5	N/A ^*
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.37x10^-5
increased circulating chloride level	1 supporting dataset	Kif1b^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.32x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kif1b.

Associated images

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Histopathology

There is no histopathology data found for Kif1b.

IMPC related publications

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External links

No external links available for Kif1b.

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*Kif1b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Kif1b^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Kif1b^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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