Apbb2 | amyloid beta precursor protein binding family B member 2

GeneMGI:108405Synonyms: TR2L, Zfra, +3 more

Physiological systems

23 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Vision/eye Respiratory system Cardiovascular system Mortality/aging

14 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

81Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



spina bifida	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
hemorrhage	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
spina bifida	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	E15.5	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Apbb2^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.03x10^-7
increased lung weight	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.71x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.48x10^-8
abnormal skin morphology	1 supporting dataset	Apbb2^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Apbb2.

Associated images

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Histopathology

There is no histopathology data found for Apbb2.

IMPC related publications

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External links

No external links available for Apbb2.

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*Apbb2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Apbb2^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Apbb2^{tm448183(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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