Sfrp2 | secreted frizzled-related protein 2

GeneMGI:108078Synonyms: Sdf5

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Growth/size/body region Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal bone structure1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult1.14x10-5 
kinked tail1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult1.53x10-8 
increased startle reflex1 supporting datasetSfrp2C50FhomozygoteEarly adult7.85x10-5 
kinked tail1 supporting datasetSfrp2C50FhomozygoteEarly adult5.45x10-7 
abnormal tail movements1 supporting datasetSfrp2C50FhomozygoteEarly adult7.12x10-5 
cornea vascularization1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult1.58x10-6 
curly tail1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult4.49x10-6 
decreased lean body mass1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult5.53x10-6 
abnormal retina vasculature morphology1 supporting datasetSfrp2tm1AkshhomozygoteEarly adult5.12x10-9 
curly tail1 supporting datasetSfrp2C50FhomozygoteEarly adult1.07x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sfrp2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Sfrp2tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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